Cambridge defender Brian Saah may reprise his role in central midfield, while Wayne Gray, Danny Wright and Robbie Willmott should all start.
Alex Stavrinou is out - his loan deal from Charlton does not expire until next week, but with the club unable to afford a renewal he will not feature.
Cambridge boss Martin Ling told BBC Radio Cambridgeshire: "We've gained some confidence from the win over Eastbourne and we're not in bad form with 17 points from 10 matches.
"But you can dress it up however you like and the games against Histon and Mansfield were frustrating.
"It's tough to have so many away games, but certainly the matches during January and February will have a massive impact on our season."
Source: BBC Sport